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Statistical test relates pathogen mutation to infectious disease progression

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Nucleic acid sequencing methods, which determine the order of nucleotides in DNA fragments, are rapidly progressing. These processes yield large quantities of sequence data -- some of which is dynamic -- that helps researchers understand how and why organisms function like they do. Sequencing also benefits epidemiological studies, such as the identification, diagnosis, and treatment of genetic and/or contagious diseases. Advanced sequencing technologies reveal valuable information about the time evolution of pathogen sequences. Because researchers can estimate how a mutation behaves under the pressure of natural selection, they are thus able to predict the impact of each mutation -- in terms of survival and propagation -- on the fitness of the pathogen in question. These predictions lend insight to infectious disease epistemology, pathogen evolution, and population dynamics. In a paper published earlier this month in the   SIAM Journal on Applied Mathematics , Ryosuke Omori an...
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UN threatens sanctions over faltering peace deal in Mali

The UN Security Council on Wednesday gave parties to a peace deal in Mali until the end of March to show progress or face sanctions for obstructing the 2015 agreement. The council unanimously adopted a French-drafted statement that “expressed a shared sense of impatience regarding the persistent delays” in making the agreement a reality on the ground. Council members “expressed their intention to follow the situation closely and to respond with appropriate steps should the parties not implement the commitments” by the end of March, the statement warned. Islamic extremists linked to Al-Qaeda took control of the desert north of Mali in early 2012, but were largely driven out in a French-led military operation launched in January 2013. Mali’s government signed a peace agreement with coalitions of armed groups in June 2015 to end the fighting, but insurgents remain active, including in central Mali. Last week, the government and two other armed groups, the Plateforme and Coordin...
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4-H fosters success in youths

“I pledge my head to clearer thinking, my heart to greater loyalty, my hands to larger service, and my health to better living, for my club, my community, my country, and my world.” Head, Heart, Hands, and Health are the four H’s of the 4-H program that youth will be engaged in through their participation in the 4-H program. Using their heads, they learn to manage many different things in their 4-H projects and life. Through their heart, they learn to relate to others and be caring to those around them and their projects. With their hands, 4-H'ers are able to work on various projects. By living healthy, they practice caring for themselves and others. How can being involved in 4-H foster youth success? In 2002, the 4-H longitudinal Study of Positive Youth Development began and was then repeated annually for eight years. More than 7,000 adolescents from across 42 states participated in the study. The Tufts research team examined how structured out-of-school time learning, leadersh...
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